Pharmacokinetics of cefodizime administered intravenously as a single-dose (1.0 and 2.0 g) to healthy adult volunteers

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Abstract
Cefodizime is a new third generation cephalosporin for parenteral use. The purpose of this study was to define the pharmacokinetic profile of cefodizime after intravenous dosing with 1.0 and 2.0 g in healthy adult volunteers. Concentrations in plasma were determined over a period of 34 h and in urine over 48 h, using high-pressure liquid chromatographic procedures. Cefodizime displays a long elimination half-life (3.5–3.7 h). Mean total clearance was 2.63±0.191/h and mean renal clearance was 1.37±0.151/h. Areas under the curve were 422±43mg.h/l and 757±39mg.h/l for 1.0 and 2.0 g respectively. The apparent volumes of distribution were 12.8± 1.81 and 14.3±1.11. After 1.0g administration the residual concentrations were 3.94±0.79 mg/l and 0.38±0.10 mg/l at 12 and 24 h, respectively; after 2.0 g administration the residual concentrations were 6.80±1.40 mg/l and 0.65±0.18 mg/l, at 12 h and 24 h. Cefodizime is mainly eliminated via the kidneys. This profile supports once-daily administration of cefodizime, when indicated in non-life-threatening infections.

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