LJP 394 (abetimus sodium, Riquent) in the management of systemic lupus erythematosus
- 1 May 2004
- journal article
- research article
- Published by SAGE Publications in Lupus
- Vol. 13 (5) , 323-327
- https://doi.org/10.1191/0961203304lu1020oa
Abstract
LJP 394 (abetimus, Riquent, La Jolla Pharmaceuticals)is four oligonucleotideB cell toleragen which acts as an ‘anti-anti DNA’. Given as a weekly infusion, Phase 1, 2, and 3 studies with this biologic on close to 1,000 patients have demonstrated no toxicity of any note. In patients with lupus nephritis and an elevated anti-DNA (Farr assay) who have a high affinity to LJP 394, the drug significantly decreases anti-DNA, improves quality of life, and trends towards reducing renal flares. LJP 394 is a promising inductionand/or maintenancetherapy for lupus patients with elevated anti-DNA and active disease.Keywords
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