2-Cyano-1,3-dicarbonyl compounds with antiallergic activity

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Abstract
A number of 2-cyanoindan-1,3-diones and 3-cyano-4-hydroxycoumarins were prepared and assessed for potential antiallergy activity as measured by their ability to inhibit passive cutaneous anaphylaxis in the rat, mediated by rat serum containing antigen specific Ig[immunoglobulin]E. The structural requirements for activity were similar not only for both series of compounds but also for the analogous 2-nitroindan-1,3-diones and 4-hydroxy-3-nitrocoumarins previously reported. The most active compounds were 2-cyano-5,6-diethylindan-1,3-dione and 3-cyano-6,7-diethyl-4-hydroxycoumarin.