Effects of Dipyridamole on the Short-Term Evolution of Glomerulonephritis
- 1 January 1991
- journal article
- clinical trial
- Published by S. Karger AG in Nephron
- Vol. 58 (1) , 13-16
- https://doi.org/10.1159/000186370
Abstract
The aim of the present study is to evaluate the effect of dipyridamole (300 mg/day) versus placebo in a double-blind randomized trial on membranous glomerulonephritis (M-GMN), mesangial IgA glomerulonephritis (IgA-GMN), and segmentary and focal hyalinosis glomerulonephritis (SFH-GMN) during the first 3 months of treatment. In the case of M-GMN, proteinuria dropped by 60% of the basal value in patients treated with dipyridamole; in the case of IgA-GMN it dropped by 65-70%; and in the case of SFH-GMN it dropped by 40% of the basal value. Inhibition of proteinuria in M-GMN was correlated to platelet response, and above all, to the ADP-induced platelet aggregation in whole blood.Keywords
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