Eosinophile Infiltration in the Pancreas of Infants of Diabetic Mothers: A Clinicopathologic Study

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Abstract
The relationship between pancreatic stromal eosinophilia, islet eosinophilia and islet hypertrophy in thirty-five infants of twenty-nine diabetic mothers has been studied with regard to multiple fetal and maternal parameters. Significant stromal eosinophilia in association with islet hypertrophy occurred only in the pancreas of infants of diabetic mothers and was unrelated to the presence of pancreatic extramedullary hematopoiesis. The presence of stromal eosinophilia was not related to the clinical grade of maternal diabetes, nor to the previous number of maternal pregnancies, nor to the administration of exogenous insulin to the mother. A statistically significant negative correlation existed between stromal eosinophilia and birth weight, length of gestation and hours of postnatal life. Islet hypertrophy showed a significant positive correlation with birth weight, suggesting that stromal eosinophilia and islet hypertrophy are independent, although associated, phenomena. No consistent change in stromal eosinophilia was noted between the first and second infants of six diabetic mothers who gave birth to more than one infant included in the study, and the presence of significant stromal eosinophilia in one infant did not preclude the subsequent birth of one or more living children by the same mother.

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