Improved Distribution of Pulmonary Flush Solution to the Tracheobronchial Wall in Pulmonary Transplantation

1 January 1997

journal article
research article
Published by S. Karger AG in European Surgical Research

Vol. 29 (1) , 1-4
https://doi.org/10.1159/000129500

Abstract

This report describes the experimental results obtained with conventional (pulmonary artery, PA) flushing versus retrograde perfusion (via left atrium, LA) using ^99mTc-labeled macroaggregated albumin (MAA-^99mTc) to ascertain the distribution throughout the tracheobronchial (TB) tree in 10 Large-White pigs. Lung preservation was achieved with 4 °C Euro-Collins solution (60 ml/kg) instilled via PA (n = 5) or LA (n = 5). Simultaneously, MAA-^99mTc was given using the same respective route and the isotope uptake quantified at different TB levels after heart-lung block harvest and dissection of all tissue adjacent to TB: proximal and distal trachea and right and left main bronchi. Retrograde distribution resulted in a significantly higher ^99mTc count compared to the PA route (p < 0.01).

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