The Influence of Sulfanilamide upon the Yellow Pigment Formed by Mycobacterium tuberculosis from p-Aminobenzoic Acid

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Abstract
Strain No. 607 American Type Culture of M. tuberculosis var. hominis was grown in Long''s medium (1) alone, and with varying concs. of (2) sulfanilamide, (3) p-aminobenzoic acid (PABA), (4) PABA plus sulfanilamide, (5) procaine, and (6) procaine with sulfanilamide. Extent of bact. growth was detd. by weighing and measuring the length of the pellicle. Color intensity of the pigment was estimated by comparison against standards of talc suspensions colored with tartrazine. Under certain conditions the formation of yellow pigment in the presence of PABA was diminished or inhibited by sulfanilamide. A hypothesis of a direct chemical reaction between the oxidation products of PABA and sulfanilamide is presented and discussed.