Reducing Ryanodine Receptor Open Probability as a Means to Abolish Spontaneous Ca 2+ Release and Increase Ca 2+ Transient Amplitude in Adult Ventricular Myocytes

Abstract
The aim of this work was to investigate whether it is possible to remove arrhythmogenic Ca2+ release from the sarcoplasmic reticulum that occurs in calcium overload without compromising normal syst...