Synergistic Effect of Fluorescein on Rose Bengal-Induced, Light-Dependent Toxicity

Abstract
The nontoxic xanthene dye fluorescein was found to synergize the toxicity of rose bengal to larvae of Aedes triseriatus (Say) upon illumination. Synergism was observed in sunlight, under fluorescent light, and upon illumination by laser light of 488.0 and 514.5 nm. Similarly, fluorescein was shown to synergize the rose bengal sensitized inhibition of glyceraldehyde-3-phosphate dehydrogenase. The study demonstrated that it is possible to enhance the photodynamic activity of rose bengal by using another dye to expand the usable range of light wavelengths.