A Comparison of the Effects of Hydrochlorothiazide and Captopril on Glucose and Lipid Metabolism in Patients with Hypertension

Publisher Website
Google Scholar
Abstract
It has been suggested that the metabolic side effects of antihypertensive drugs are responsible for their failure to reduce cardiovascular morbidity in patients with hypertension. Therefore, in 50 patients with essential hypertension, we performed a randomized, double-blind, crossover study comparing the effects on carbohydrate and lipid metabolism of captopril (mean [±SD] dose, 81±24 mg per day) and hydrochlorothiazide (40±12 mg per day) over two four-month treatment periods.