ANTISECRETORY EFFECTS OF 2 NEW HISTAMINE H-2-RECEPTOR ANTAGONISTS

  • 1 January 1986
    • journal article
    • research article
    • Vol. 36-2  (9) , 1358-1363
Abstract
N-{3-[3-(1-Piperidinylmethyl)phenoxy]propyl} acetoxyacetamide hydrochloride (Hoe 760) and N-{-[3-(1-piperidinylmethyl)phenoxy]propyl}glycolamide hydrochloride (Hoe 062) are highly specific H2-receptor antagonists. The compounds are equipotent after intragastrical or intravenous administration. The antagonists inhibited gastric acid secretion in the rat induced by all stimuli tested, carbachol, desglugastrin and histamine. In the Heidenhain pouch dog whose gastric acid secretion was stimulated by food or histamine the two receptor blockers proved to be 4-6 times more potent inhibitors than cimetidine.