Long-Term Treatment of an Infant with Nesidioblastosis Using a Somatostatin Analogue

Publisher Website
Google Scholar
Abstract
To the Editor: Nesidioblastosis is a condition of inappropriate insulin secretion.1 2 3 Treatment consists of normalizing the glucose level with insulin-suppressive drugs or glucagon. Subtotal or even total removal of the pancreas may be necessary. A female Moroccan newborn was admitted to the hospital directly after birth with asphyxia and convulsions. Laboratory examination revealed hypoglycemia (14 mg per deciliter) with an elevated serum insulin level (76 mU per liter). Glucose infusions with diazoxide treatment did not restore normoglycemia. When the child was four weeks of age, subtotal pancreatectomy was performed; histologic examination showed nesidioblastosis. When she was 8.5 months old, hypoglycemia . . .