Studiesin vivoon the efficacy of enrofloxacin againstMycoplasma gallisepticum

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Abstract
After a 5‐day medication with drinking water containing 50 ppm enrofloxacin, Mycoplasma gallisepticum (MG) was culturally reisolated in only one of 80 broiler chicks and specific antibodies to MG were detected in none of the 40 birds tested. Medication with 50 ppm for 3 days and 25 ppm for 5 days was only slightly less effective. A significant decline in efficacy was observed, however, when enrofloxacin was added to the drinking water at 50 ppm for 1 day or 12.5 ppm for 5 days. Tiamulin was also significantly effective (250 ppm, 3 days). However, measured by the cultural reisolation of the pathogen and the presence of antibodies to MG. enrofloxacin (50 ppm, 3 days) proved to be more effective. Treatment with tylosin (50 ppm. 5 days) conferred no significant protection.