Identification and characterization of rod-derived cone viability factor
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Open Access
- 27 June 2004
- journal article
- letter
- Published by Springer Nature in Nature Genetics
- Vol. 36 (7) , 755-759
- https://doi.org/10.1038/ng1386
Abstract
Retinitis pigmentosa is an untreatable, inherited retinal disease that leads to blindness. The disease initiates with the loss of night vision due to rod photoreceptor degeneration, followed by irreversible, progressive loss of cone photoreceptor1,2,3. Cone loss is responsible for the main visual handicap, as cones are essential for day and high-acuity vision4. Their loss is indirect, as most genes associated with retinitis pigmentosa are not expressed by these cells. We previously showed that factors secreted from rods are essential for cone viability5,6,7,8. Here we identified one such trophic factor by expression cloning and named it rod-derived cone viability factor (RdCVF). RdCVF is a truncated thioredoxin-like protein specifically expressed by photoreceptors. The identification of this protein offers new treatment possibilities for retinitis pigmentosa.Keywords
This publication has 18 references indexed in Scilit:
- The mystery of nonclassical protein secretionEuropean Journal of Biochemistry, 2003
- Neurotrophic Rescue of Photoreceptors: Are Müller Cells the Mediators of Survival?Neuron, 2000
- Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research, 1997
- Photoreceptor Transplants Increase Host Cone Survival in the Retinal Degeneration (rd) MouseOphthalmic Research, 1997
- Digenic Retinitis Pigmentosa Due to Mutations at the Unlinked Peripherin/ RDS and ROM1 LociScience, 1994
- Recessive mutations in the gene encoding the β–subunit of rod phosphodiesterase in patients with retinitis pigmentosaNature Genetics, 1993
- A Null mutation in the rhodopsin gene causes rod photoreceptor dysfunction and autosomal recessive retinitis pigmentosaNature Genetics, 1992
- Adult T-cell leukemia-derived factor/thioredoxin, produced by both human T-lymphotropic virus type I- and Epstein-Barr virus-transformed lymphocytes, acts as an autocrine growth factor and synergizes with interleukin 1 and interleukin 2.Proceedings of the National Academy of Sciences, 1990
- Plasticity and Differentiation of Embryonic Retinal Cells After Terminal MitosisScience, 1989
- High-efficiency transformation of mammalian cells by plasmid DNA.Molecular and Cellular Biology, 1987