Changes of blood pressure and regional blood flow in SART rats and drug actions on these changes

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Abstract
The function of the circulatory system in SART rats was investigated by examining systolic blood pressure and regional arterial blood flow. In SART stressed rats blood pressure was .apprx. 10 mm Hg lower than that of the non-stressed group on the 6th day of stressing and after stressing low blood pressure was maintained for several days. SART rats showed a decrease in the average blood flow value in the common carotid artery, increases in the average and instantaneous maximum blood flow values in the superior mesenteric artery and the instantaneous maximum blood flow value in the abdominal aorta increased, though little changes were observed in the renal and the femoral arteries. There was evidently hardening in the vessel walls of the common carotid artery and the abdominal aorta and softening in the superior mesenteric artery. SART stress-induced hypotension was further decreased by a single dose of guanethidine, clonidine or hydralazine, but not by neurotropin. Continuous preadministration of neurotropin prevented the SART stress-induced hypotension and changes in blood flow. The sympathetic nerve may be decreased in tension or depressed in the circulatory system of SART rats.