Cannabinoids in Glaucoma: A Primary Screening Procedure

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Abstract
A procedure was developed for screening of cannabinoids for their ability to reduce intraocular pressure (IOP) using normal rabbits. Eight animals per group were used for statistical significance of data. A negative control group was used for every screen as well as a positive control with 1.5 mg/kg Δ9‐THC given intravenously (I.V.). All compounds were tested by I.V. injection and IOP measurements were taken periodically for 5 hours. Data were analyzed by a computer program which takes into account the change in IOP of the control group. Following this procedure we found that Δ8‐THC, Δ9‐THC, cannabinol, and nabilone were active while cannabidiol was inactive.