Follicular Helper CD4 T Cells (TFH)
Top Cited Papers
- 23 April 2011
- journal article
- review article
- Published by Annual Reviews in Annual Review of Immunology
- Vol. 29 (1) , 621-663
- https://doi.org/10.1146/annurev-immunol-031210-101400
Abstract
T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of immunological memory. Follicular helper CD4 T (TFH) cells are the specialized providers of B cell help. TFHcells depend on expression of the master regulator transcription factor Bcl6. Distinguishing features of TFHcells are the expression of CXCR5, PD-1, SAP (SH2D1A), IL-21, and ICOS, among other molecules, and the absence of Blimp-1 (prdm1). TFHcells are important for the formation of germinal centers. Once germinal centers are formed, TFHcells are needed to maintain them and to regulate germinal center B cell differentiation into plasma cells and memory B cells. This review covers TFHdifferentiation, TFHfunctions, and human TFHcells, discussing recent progress and areas of uncertainty or disagreement in the literature, and it debates the developmental relationship between TFHcells and other CD4 T cell subsets (Th1, Th2, Th17, iTreg).Keywords
This publication has 288 references indexed in Scilit:
- Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell LineageImmunity, 2010
- Optimal Germinal Center Responses Require a Multistage T Cell:B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84Immunity, 2010
- Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancerCytokine & Growth Factor Reviews, 2010
- Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription FactorsImmunity, 2009
- A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral InfectionImmunity, 2009
- Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell PropertiesPublished by Elsevier ,2009
- Patients with X-linked lymphoproliferative disease due to BIRC4 mutation have normal invariant natural killer T-cell populationsClinical Immunology, 2009
- Phenotypic differences between mice deficient in XIAP and SAP, two factors targeted in X-linked lymphoproliferative syndrome (XLP)Cellular Immunology, 2009
- The effects of IL-6 on CD4 T cell responsesClinical Immunology, 2009
- Development of autoimmune hepatitis–like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuatorArthritis & Rheumatism, 2008