Inhibition by azelastine of the immunologically induced histamine release from isolated guinea pig mast cells.

  • 1 January 1981
    • journal article
    • Vol. 31  (8) , 1193-5
Abstract
4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1-(2H)-phthalazinone (azelastine, A 5610) did not affect the spontaneous histamine release but inhibited effectively the allergic histamine release from isolated mesenteric mast cells of actively sensitized guinea pigs. At 10(-6) mol/l concentration the inhibition was almost equal to that caused by adrenaline (10(-8) mol/l).

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