EFFECT OF ASCORBIC ACID ON THE PITUITARY-THYROID SYSTEM IN THE RAT

Publisher Website
Google Scholar
Abstract
Department of Zoology, Brigham Young University, Provo, Utah 84602, U.S.A. (Received 3 February 1976) Acute ascorbic acid depletion in guinea-pigs has been shown to be accompanied by increased uptake of 131I by the thyroid in vivo (Beaton, Hellebust, Paul & Wright, 1960; Kassouny & Rivers, 1972). However, as this vitamin deficiency progresses there is subsequent inanition and weight loss. Under these conditions uptake of 131I in vitro and organification is decreased (Kassouny & Rivers, 1971, 1972). Increased peripheral de-iodination of thyroxine (T4) and tri-iodothyronine (T3) has been reported in guinea-pigs fed a low vitamin C diet (Hsu, 1969). Rats fed 10 mg ascorbic acid on alternate days for 21 days had greater than normal thyroidal uptake of 131I but this was lower than normal in animals fed 40 mg on alternate days (Mallick & Deb, 1975). Qualitatively, similar results were obtained in guinea-pigs (Deb & Mallick, 1974). The effect of

This publication has 0 references indexed in Scilit: