EXCRETION OF INULIN, CREATININE, XYLOSE AND UREA IN THE NORMAL RABBIT

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Abstract
The clearances of all 4 substances increased with increasing urine flow, and failed to reach a constant value at urine flows that were maximal under the conditions of the expts. Simultaneous clearances of inulin and creatinine were equal, regardless of urine flow or plasma level of creatinine. The change in the inulin and creatinine clearances in relation to changing urine flow is interpreted as indicating a corresponding change in glomerular activity. . The xylose and urea clearances, both in simultaneous and independent observations, were considerably less than the creatinine-inulin clearance. When water is administered by stomach in excessive amounts it leads paradoxically to oliguria, convulsions and death. Water intoxication appears to be favored by intraven. injections. This phenomenon, coupled with the physiological relationship between glomerular activity and water excretion, should be considered in renal function studies in the rabbit.

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