Inhibition of human erythrocyte and plasma cholinesterases by methamidophos
- 1 August 1982
- journal article
- research article
- Published by Wiley in Journal of Applied Toxicology
- Vol. 2 (4) , 217-218
- https://doi.org/10.1002/jat.2550020410
Abstract
Methamidophos (O, S‐dimethyl phosphoramidothioate) inhibition of human erythrocyte and plasma cholinesterase was studied in vitro. The pseudo‐biomolecular rate constant of inhibition was 3.14 ± 0.22 × 103 M−1 min−1 for erythrocyte cholinesterase and 1.85 ± 0.01 × 103 M−1 min−1 for plasma cholinesterase. Thus methamidophos, although quite toxic to mammals, is a slow, rather non‐selective inhibitor of human cholinesterases, as was also observed previously in rats.Keywords
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