NMR Structural Analysis of a Modular Threading Tetraintercalator Bound to DNA
- 13 October 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (43) , 14036-14042
- https://doi.org/10.1021/ja046335o
Abstract
The synthesis and NMR structural studies are reported for a modular threading tetraintercalator bound to DNA. The tetraintercalator design is based on 1,4,5,8-tetracarboxylic naphthalene diimide units connected through flexible peptide linkers. Aided by an overall C2 symmetry, NMR analysis verified a threading polyintercalation mode of binding, with linkers alternating in the order minor groove, major groove, minor groove, analogous to how a snake might climb a ladder. This study represents the first NMR analysis of a threading tetraintercalator and, as such, structurally characterizes a new topology for molecules that bind to relatively long DNA sequences with extensive access to both DNA grooves.Keywords
This publication has 19 references indexed in Scilit:
- Changing DNA Grooves − A 1,4,5,8-Naphthalene Tetracarboxylic Diimide Bis-Intercalator with the Linker (β-Ala)3-Lys in the Minor GrooveJournal of the American Chemical Society, 2002
- The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sitesNature Structural & Molecular Biology, 2001
- Designed Sequence-Specific Minor Groove LigandsAnnual Review of Biophysics, 2000
- Arrays with Local Centers of Symmetry in Space Groups Pca21 and Pna21Acta crystallographica Section B, Structural science, crystal engineering and materials, 1998
- Recognition of 16 Base Pairs in the Minor Groove of DNA by a Pyrrole−Imidazole Polyamide DimerJournal of the American Chemical Society, 1998
- A New Class of Polyintercalating MoleculesJournal of the American Chemical Society, 1997
- Structure-Based Design of a New Bisintercalating Anthracycline AntibioticJournal of Medicinal Chemistry, 1997
- DNA structural formsQuarterly Reviews of Biophysics, 1996
- Sequence-Specific Cleavage of Double Helical DNA by Triple Helix FormationScience, 1987
- Molecular characterization of small polydisperse circular DNA from an African green monkey cell lineBiochemistry, 1982