SPONTANEOUS NEPHROTIC SYNDROME IN A GENETIC RAT MODEL

  • 1 January 1984
    • journal article
    • research article
    • Vol. 117  (3) , 400-408
Abstract
The rat strain used was obtained by Koletsky after selective inbreeding of the offspring from a hypertensive Kyoto-Wistar and a normotensive Sprague-Dawley rat. The affected animals appeared in 25% of the litters, indicating an autosomal recessive gene and presented a spontaneous and progressive nephrotic syndrome detected as early as 3-5 wk and associated with obesity, hypertension, hypoaluminemia, hypercholesterolemia and hyperlipidemia. Preliminary morphologic and immunofluorescence studies of their kidneys showed progressive glomerular segmental sclerotic lesions and prominent mesangial deposition of IgM, a picture which resembles a steroid-resistant form of idiopathic nephrotic syndrome in humans, namely, focal glomerular sclerosis.