COMPARATIVE METABOLISM OF RADIONUCLIDES IN MAMMALS—XL RETENTION OF 113Sn IN THE MOUSE, RAT, MONKEY AND DOG*

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Abstract
Stannous chloride was injected by oral (IG), i.p. and i.v. routes into mice, rats and African white-tailed rats [Mystiomys albicaudatus] and by IG and i.v. routes into monkeys [Macaca mulatta] and dogs. Less than 5% was absorbed from the gut. There was much similarity in retention patterns following parenteral administration, and the small amount absorbed from the gut in conjunction with the discontinuous nature of fecal excretion resulted in similar patterns after ingestion of Sn. Bone was the chief site of Sn deposition. The biological inertness of Sn results in a low order of toxicity. The radiation protection guides set by the International Commission of Radiological Protection in 1960 appear to be adequate.