The frequency of apolipoprotein E4 allele is not increased in patients with probable vascular dementia
- 1 May 1996
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 93 (5) , 352-354
- https://doi.org/10.1111/j.1600-0404.1996.tb00008.x
Abstract
We used the NINDS‐AIREN criteria to diagnose vascular dementia (VD), and compared apolipoprotein E (apoE) allele frequencies and apoE concentrations in serum and cerebrospinal fluid (CSF) between patients with possible (n=19) and probable (n = 33) VD and controls (n=105). There was no difference in apoE4 frequency between patients with probable VD and controls. Serum and CSF apoE concentrations did not differ between VD patients and contols. Our results suggest that apoE plays no role in the development of VD.Keywords
This publication has 9 references indexed in Scilit:
- Complete cerebral ischemia with short-term survival in rat induced by cardiac arrest. II. Extracellular and intracellular accumulation of apolipoproteins E and J in the brainBrain Research, 1995
- Apolipoprotein E (apoE) polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer's diseaseHuman Genetics, 1995
- Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vascular dementia.Journal of Neurology, Neurosurgery & Psychiatry, 1994
- Association of the apolipoprotein E ϵ4 allele with clinical subtypes of autopsy‐confirmed Alzheimer's diseaseAmerican Journal of Medical Genetics, 1994
- Clinical-Neuropathological Correlations in Alzheimer's Disease and Related DementiasArchives of Neurology, 1994
- Reliability of NINDS‐AIREN clinical criteria for the diagnosis of vascular dementiaNeurology, 1994
- Vascular dementiaNeurology, 1993
- Plasma apolipoproteins in patients with multi-infarct dementiaAtherosclerosis, 1989
- Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell BiologyScience, 1988