Nasopharyngeal Carcinoma in an Alaskan Eskimo Family: Report of three Cases

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Abstract
Nasopharyngeal carcinoma (NPC) has been reported to occur in Alaska Natives (Eskimos, Indians, and Aleuts) at a rate greater than 15 times the rate for U.S. whites. At least 3 cases of NPC have occurred in close relatives of a Northern Alaskan Eskimo family. All 3 patients had poorly differentiated tumors and have died. Blood group, HLA antigens, and antibodies to Epstein-Barr virus (EBV) were studied in the family members. EBV titers were elevated in the 1 NPC patient tested and in 1 of 15 other family members tested. All family members studied except 1 were of blood group A, Rh-positive, and HLA types AW24, CW3, 8W401A2, CW2, and 827. This was the first report of more than 2 casesof NPC in a single family in the United States

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