Effect of Starvation on the Production and Peripheral Metabolism of 3,3′,5′-Triiodothyronine in Euthyroid Obese Subjects*
- 1 October 1978
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 47 (4) , 889-893
- https://doi.org/10.1210/jcem-47-4-889
Abstract
The effect of starvation on the peripheral metabolism of rT3 was evaluated in four obese euthyroid patients. During starvation, the serum rT4 concentration increased by 69% while the MCR of rT4 decreased in all four patients from control values of 96 ± 23 (mean ± SD) to 68 ± 17 liters/70 kg day, resulting in a slight increase in the mean production rate of rT3. These findings are in contrast to the marked decrease in T3 production rate associated with fasting, indicating that inner and outer ring deiodination of T4 can be varied independently.Keywords
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