PITUITARY-DIABETES IN THE CAT: RECOVERY FOLLOWING PHLORHIZIN TREATMENT1

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Abstract
The production of pituitary-diabetes in the cat, the course of the lesions in the islands of Langerhans and the recovery of animals given early treatment with insulin were reported (Endocrinology 30: 175, 1942). Treatment of this type of diabetes by phlorhizin, if begun within the first 3 mos., was followed by morphological restoration of the islands and functional recovery of the animals. In addition, injury to the pancreatic islands was prevented when phlorhizin was administered simultaneously with diabetogenic pituitary extract. Phlorhizin abolished the usual hyperglycemic effect of the extract without inhibiting gluconeogenesis, ketogenesis or thyro-trophic activity. The primary action of phlorhizin on the kideny and its secondary effects on metabolism were quite different from the action of insulin, although both drugs lower the blood sugar in diabetic animals. The action of phlorhizin and that of insulin were compared. The results emphasize the possible importance of the level of blood glucose in the pathogenesis and recovery of early exptl. diabetes.

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