Deleterious Effects of Privine Hydrochloride

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Abstract
To the Editor: Privine hydrochloride, as 0.10 and 0.05 per cent solutions, was introduced in 1942 as a nasal vasoconstrictor. The advantages claimed for Privine were prolonged vasoconstriction, small dosage and physiologic rationale. The dose of Privine is two to three drops nasally, and it produces symptomatic relief from the nasal congestion for two to six hours. Since it is prepared in isotonic solution buffered to the same pH as that of the "delicate nasal mucous membranes," it was said to be nonirritating; furthermore, it was claimed that it restores the alkaline pathologic secretions to the normal acid range. . . .

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