Cytomegalovirus Syndrome in Children With Acute Leukemia
- 21 August 1967
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 201 (8) , 612-615
- https://doi.org/10.1001/jama.1967.03130080054013
Abstract
The incidence of cytomegalic inclusion disease (CMID) has shown a significant increase in recent years in children receiving intensive chemotherapy for acute leukemia1,2and in patients receiving immunosuppressive drugs following renal transplantation.3,4The clinical course of CMID in two children with acute leukemia who died with extensive interstitial pneumonitis due to cytomegalovirus (CMV) infection has been described.2The simultaneous use of several antineoplastic agents apparently suppresses immunologic responses to a clinically significant degree. Antiviral effects of floxuridine (2′-deoxy-5-fluorouridine or FUDR) have been demonstrated conclusively. In infected tissue cultures, floxuridine prevents the formation of infectious CMV particles and of intranuclear inclusions; these effects may be prevented by simultaneous treatment of the infected culture with thymidine.5In the previously reported case of a child with CMID complicating acute leukemia, floxuridine therapy produced transient improvement.2 The purpose of this paper is to evaluate further the effects of floxuridineKeywords
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