Cobalt mediated regioselective alkylation of methyl 3,5-dioxohexanote. Preparation of 5-alkyl derivatives of 4-hydroxy-6-methyl-2-pyrone
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 9,p. 644-645
- https://doi.org/10.1039/c39870000644
Abstract
The cobalt(II) complex of the simple polyketide model methyl 3,5-dioxohexanoate is regioselectively alkylated to afford methyl 4-alkyl-3,5-dioxohexanoates, which cyclize on treatment with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to give 5-alkyl-4-hydroxy-6-methyl-2-pyrones.Keywords
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