A STUDY OF ACUTE RENAL INSUFFICIENCY 1
Open Access
- 1 November 1939
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 18 (6) , 777-781
- https://doi.org/10.1172/jci101094
Abstract
The low variability of the survival time of the standard nephrectomized rat makes it an excellent test object for the study of the toxic mechanisms in renal insufficiency and for the study of the efficiency of different therapeutic measures in this condition. Immature rats have definitely shorter survival times than the adult. Fasting brings about a slight prolongation of life. Meat (fed immediately before operation) is definitely toxic. The urine of fasted rats contains toxic materials but the amt. of these poisons is not enough to account quantitatively for the entire toxic condition which supervenes after nephrectomy. K is harmful and is responsible for part of the toxicity of meat.This publication has 0 references indexed in Scilit: