Carrageenan oedema and spinal Fos-LI neurones are reduced by piroxicam in the rat

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Abstract
INTRAPLANTAR carrageenan induced a peripheral oedema and c-Fos like immunoreactivity (Fos-LI) in L4–L5 segments in the dorsal horn (DH) of the rat spinal cord. The total number of carrageenan evoked Fos-LI neurones was 153±10 per section, with a predominant localization in the superficial and deep laminae of the DH (46±4% and 32±2%, respectively). Pre-administered piroxicam (1, 2.5 and 5 mg kg-1, p.o.) dose-dependently reduced the number of Fos-LI neurones in both the superficial and deep laminae of DH, with effects being significantly strongest on the deep laminae Fos-LI neurones. The effects of piroxicam on the number of spinal Fos-LI neurones and on ankle oedema were positively correlated.

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