On the Transfer of DNP-BSA Hypersensitivity in Guinea Pigs by Means of Irradiated Donor Plasma. Evidence That the Cutaneous Reactivity Is Hapten-Specific and Mediated Via DNP Antibody

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Abstract
Cutaneous sensitivity to 2,4-dinitrophenylated bovine serum albumin was transferred with plasma from sensitized, irradiated guinea pigs following the procedure of Dupuy and Good (1). Enhanced cutaneous reactivity was observed in recipients of plasma from irradiated (800 rads) donors as compared to plasma from nonirradiated donors. Cutaneous reactions of plasma recipients were greater at 3 to 4 hr than at 24 hr after skin testing and they exhibited clear-cut hapten, as opposed to carrier, specificity. The plasma used to transfer this sensitivity contained precipitating antibody which also was hapten-specific. These data demonstrate that the transferred sensitivity was “immediate” and due to circulating, precipitating DNP antibody producing a toxic antigen-antibody complex reaction of the Arthus type.

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