Donnan equilibrium effects in protein crystallisation

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  • 23 January 2002
Abstract
It is argued that a natural explanation for the scaling collapse of crystallisation boundaries observed for lysozyme [Poon et al, J. Phys. Cond. Mat. 12, L569 (2000)] can be found by incorporating the idea of a Donnan equilibrium between solution and crystal phases into existing theories for protein phase behaviour. The same theory also explains much of the salt-dependence of the second virial coefficient. The analysis has wider implications for the use of pair potentials to understand protein crystallisation.

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