Sex Differences in Secondary Attack Rate of IDDM to Siblings of Probands Through Older Ages: Pittsburgh Etiology of IDDM Study
- 1 April 1992
- journal article
- research article
- Published by American Diabetes Association in Diabetes Care
- Vol. 15 (4) , 559-561
- https://doi.org/10.2337/diacare.15.4.559
Abstract
Objectives To determine the descriptive epidemiological patterns of the secondary attack rate of insulin-dependent diabetes mellitus (IDDM) among siblings of probands through older ages. Research Design and Methods A family history analysis was performed on 1774 IDDM probands who were diagnosed or seen within 1 yr of diagnosis at Children9s Hospital of Pittsburgh from 1 January 1950 through 31 December 1981. The probands were discharged on insulin and were diagnosed at P = 0.01). There was no evidence of an excess sex concordance among affected sibling pairs. Conclusions Males have a greater secondary attack rate of IDDM at older ages than females. This may be due to an increased exposure to environmental agents among males or protective influences operating among females.Keywords
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