INHIBITION OF RADIATION CARCINOGENESIS IN MICE BY S-2-(3-AMINOPROPYLAMINO)-ETHYLPHOSPHOROTHIOIC ACID

  • 1 January 1984
    • journal article
    • research article
    • Vol. 44  (12) , 5567-5569
Abstract
S-2-(3-aminopropylamino)ethyl-phosphorothioic acid (WR-2721) given to mice prior to ionizing radiation inhibits development of radiation-induced sarcomas. The right hind legs of C3Hf/Kam mice were exposed to single doses of .gamma.-rays ranging from 3400-5700 rads. Thirty min before irradiation, .apprx. 1/2 of the mice were given i.p. injections of WR-2721 (400 mg/kg). Mice were checked for development of radiation-induced tumors within the irradiated tissue of legs from 250 upto 786 days after irradiation. Tumors 1st appeared in both groups of mice at .apprx. 300 days after irradiation. Thereafter, the rate of tumor development was slower in mice that received both WR-2721 and leg irradiation. At the end of the observation period, the overall actuarial tumor incidence in these mice was 26%, compared to 87% in mice exposed to radiation only. Since WR-2721 has the ability to protect against radiation carcinogenesis, it may also afford protection against the carcinogenic effect of alkylating agents. [The use of this agent during radiation and chemotherapy was outlined.].