Identification of a novel monocyte cell surface molecule involved in the generation of antigen-induced proliferative responses

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Abstract
A monocyte molecule, identified by a monoclonal antibody (mAb) named 24, is involved in the antigen‐specific proliferation of T cells. Several types of antigen‐induced responses are blocked by mAb 24, but mitogen responses, even at low doses, are not. The 24 molecule is found on circulating monocytes and no other cell type. Normally only a proportion of monocytes express the 24 molecule but it can be induced rapidly on monocytes in culture, possibly from intracellular sources. The epitope is present on a heterodimer of 175 and 95 kDa which is similar to the leukocyte cell adhesion molecule (Leu‐CAM) family. These findings suggest that although the 24 molecule shows some functional and biochemical similarities with the Leu‐CAM family of molecules, it represents a novel structure primarily associated with mononuclear phagocytes.