GLYCOPYRRONIUM REQUIREMENTS FOR ANTAGONISM OF THE MUSCARINIC SIDE EFFECTS OF EDROPHONIUM †
Open Access
- 1 January 1989
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 62 (1) , 77-81
- https://doi.org/10.1093/bja/62.1.77
Abstract
We have compared, in 60 adult patients, the cardiovascular effects of glycopyrronium 5 µg kg−1 and 10 µg kg−1 given either simultaneously or 1 min before edrophonium 1 µg kg−1. Significant differences between the four groups were detected (P < 0.001). Both groups receiving 10 µg kg−1 showed increases in heart rate of up to 30 beat min-1 (95% confidence limits 28–32 beat min-1). Use of glycopyrronium 5 µg kg−1 provided greater cardiovascular stability and, given 1 min before the edrophonium, was sufficient to minimize early, edrophonium-induced bradycardias. This low dose of glycoprronium provided good control of oropharyngeal secretions.Keywords
This publication has 1 reference indexed in Scilit:
- COMPARISON OF THE EFFECTS OF ATROPINE AND GLYCOPYRROLATE ON COGNITIVE FUNCTION FOLLOWING GENERAL ANAESTHESIABritish Journal of Anaesthesia, 1987