The measurement of plasma concentration of aminopyrine and its metabolites in man.
- 1 January 1978
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 26 (1) , 33-37
- https://doi.org/10.1248/cpb.26.33
Abstract
By means of mass fragmentography using the isotope dilution method, the measurement of the [human] plasma concentration of aminopyrine (AM) and its metabolites was performed successfully. From the plasma concentration-time curve, the individual differences were observed in 2 processes which are demethylation of AM to 4-monomethylaminoantipyrine (MAA) or MAA to 4-aminoantipyrine (AA) and acetylation of AA to 4-acetylaminoantipyrine. A quantitative correlation between the plasma concentration and the amount of urinary excretion was discussed.This publication has 1 reference indexed in Scilit:
- Metabolism and excretion of aminopyrine in man.CHEMICAL & PHARMACEUTICAL BULLETIN, 1976