Muramyl Dipeptide Enhances Survival From Experimental Peritonitis
- 1 January 1986
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Surgery
- Vol. 121 (1) , 47-49
- https://doi.org/10.1001/archsurg.1986.01400010053006
Abstract
• Muramyl dipeptide is a nonspecific immunostimulant derived from Freund's complete adjuvant. We determined the effect of muramyl dipeptide on two separate animal models for peritonitis. We found that administration of muramyl dipeptide to rats undergoing cecal ligation and puncture significantly reduced mortality. Similarly, mice that underwent cecal ligation alone with muramyl dipeptide administration also had a statistically significant reduction in mortality compared with untreated controls. (Arch Surg 1986;121:47-49)Keywords
This publication has 6 references indexed in Scilit:
- Nonspecific Stimulation of Host Defenses Against Bacterial Challenge in Immunosuppressed MiceArchives of Surgery, 1983
- Nonspecific Enhancement of Resistance to Bacterial InfectionAnnals of Surgery, 1982
- Sepsis and septic shock—A review of laboratory models and a proposalJournal of Surgical Research, 1980
- Secondary bacterial peritonitis: The biologic basis of treatmentCurrent Problems in Surgery, 1979
- The macrophage, target cell of the synthetic adjuvant muramyl dipeptideEuropean Journal of Immunology, 1978
- Modulation of the immune response by a synthetic adjuvant and analogs.Proceedings of the National Academy of Sciences, 1976