Comparative Metabolism of Carbaryl by Resistant and Susceptible Strains of the Cabbage Looper12

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Abstract
The in vivo and in vitro metabolism of carbaryl by susceptible, DDT-resistant, and parathion-resistant strains of Trichoplusia ni (Hübner) larvae was studied and respect compared. In each strain, maximum carbaryl-metabolizing activity was found in the fat body, and this activity was greatest in last larval stage and prepupal forms. Homogenate’s of gut and fat body tissues contained cytochrome P-450 and a mixed-function oxidate (s) which was inhibited by carbon monoxide and methylcnedioxy-phenyl synergists. Fat body from a parathion-resistant strain was 8 times and 4 times as active as fat body from a susceptible strain and a DDT-resistant strain, respectively. The in vivo half-lives of carbaryl in the susceptible. DDT-resistant, and parathion-resistant 1coopers were 13. 8, and 3 minutes. The major metabolite formed in vivo and in vitro by all strains was hydroxymethyl carbaryl.

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