Genome Scale Identification ofTreponema pallidumAntigens
- 1 July 2005
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (7) , 4445-4450
- https://doi.org/10.1128/iai.73.7.4445-4450.2005
Abstract
Antibody responses for 882 of the 1,039 proteins in the proteome ofTreponema pallidumwere examined. Sera collected from infected rabbits were used to systematically identify 106 antigenic proteins, including 22 previously identified antigens and 84 novel antigens. Additionally, sera collected from rabbits throughout the course of infection demonstrated a progression in the breadth and intensity of humoral immunoreactivity against a representative panel ofT. pallidumantigens.Keywords
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