Epidermal Nucleolar IgG Deposition in Clinically Normal Skin

Abstract
• Epidermal nucleolar IgG deposition in clinically normal skin reflects high serum concentrations of antibody to nucleolar antigen. This immunopathologic finding occurred in six patients with scleroderma and in two patients with a scleroderma-systemic lupus erythermatosus overlap syndrome. (Arch Dermatol 114:536-538, 1978)