T Cell Receptor-Bearing Lymphocytes during Epstein-Barr Virus Infection
- 1 May 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 161 (5) , 1013-1016
- https://doi.org/10.1093/infdis/161.5.1013
Abstract
Lymphocytes bearing γδ T cell receptors (1CR) constitute a minor subpopulation of human peripheral blood lymphocytes. Their role and function during microbial infections are largely unknown. In 10 patients with Epstein-Barr virus-induced infectious mononucleosis, the γδ TCR-expressing T cell population expanded during the acute phase. These cells were largely δTCS1-, CD4-, and CD8- but expressed activation antigens such as human leukocyte antigen-DR and CD38. The convalescent phase of infectious mononucleosis was characterized by a relative persistence of γδ T cells. Together these data suggest a possible role of γδ T cells in the control of primary Epstein-Barr virus infection in humans.Keywords
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