SOME CONSTITUENTS OF THE URINE OF NORMAL AND SCHIZOPHRENIC INDIVIDUALS: PART II

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Abstract
A comparison has been made of the compounds detectable on two-dimensional paper chromatograms by their ultraviolet absorption or fluorescence, or by development with diazotized sulphanilics acid (DSA), in extracts of the urines of normal and schizophrenic individuals. No significant difference could be detected. Of the six DSA coupling compounds reported in Part I (1) to have a possible connection with schizophrenia, only four were detected in this survey and their distribution in the urine samples does not suggest that any have a connection with the disease. Most of the compounds reported in Part I were found again in this survey along with 70 DSA or Altman-positive new materials of which many were present in only a few samples. A small number of additional compounds were detected in the urine of schizophrenics on Chlorpromazine or Reserpine therapy. No significant difference between the human pseudocholine esterase inhibitory properties of the extracts from normal and schizophrenic urines was observed.