Differences in Anionic Dependence of the Synaptic Efflux of d‐Aspartic Acid and γ‐Aminobutyric Acid
- 1 September 1986
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 47 (3) , 687-690
- https://doi.org/10.1111/j.1471-4159.1986.tb00666.x
Abstract
The synaptosomal effluxes of D-aspartate and .gamma.-aminobutyric acid (GABA) induced by a substitution of the Cl- ions with propionate in the incubation medium were measured in preparations of hippocampal tissue homogenates. The efflux of aspartate was significantly higher than spontaneous efflux at 125 mM Cl- (normal = 144 mM) and was increased with decreasing Cl- concentration. GABA efflux was much less sensitive to a reduction in Cl- concentration than D-aspartate. The efflux was Ca2+-dependent in both cases.Keywords
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