Renal circulation during stop flow in the dog

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Abstract
Renal circulation during ureteral occlusion has been studied in the dog during osmotic diuresis. Renal blood flow was determined by the simultaneous measurements of venous outflow (direct RBF) and 86Rb uptake (RBF-86Rb), and renal regional blood flows on the basis of the 86Rb content of cortex, outer and inner medulla. During free urine flow the direct RBF (mean 357 ml/min/100 g) agreed well with the RBF-86Rb (mean 371 ml/min/100 g). After ureteral occlusion direct RBF increased to an average of 400 ml/min/100 g, whereas RBF-86Rb decreased to 221 ml/min/100 g. The ratio of cortical 86rb blood flow to total renal blood flow (RBF-86Rb in free flow, direct RBF during stop flow of urine), diminished from 0.78 to 0.48, the EPAH [para amino hippurate elimination] from 0.75 to 0.52, on the average. The difference between the values obtained by direct estimation of RBF and by the 86Rb method with the comparable reduction of EPAH is ascribed to the opening of A-V shunts.