Chiral Preparation of (R)- and (S)-3-(Benzyloxy)-4,4-dimethyl-1-pentene
- 1 January 1993
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1993 (01) , 137-140
- https://doi.org/10.1055/s-1993-25817
Abstract
Facile routes for the preparation of an optically active allylic ether bearing the tert-butyl group at an allylic chiral center, i.e. 2-(benzyloxy)-3,3-dimethyl-1-pentene, in both (R)- and (S)-enantiomeric forms, which are expected to be promising, efficient dipolarophiles in highly stereoselective asymmetric nitrone cycloaddition, have been developed, utilizing commercially available L-tert-leucine and (R)-pantolactone, respectively, as chiral precursors.Keywords
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