Chiral Preparation of (R)- and (S)-3-(Benzyloxy)-4,4-dimethyl-1-pentene

Abstract
Facile routes for the preparation of an optically active allylic ether bearing the tert-butyl group at an allylic chiral center, i.e. 2-(benzyloxy)-3,3-dimethyl-1-pentene, in both (R)- and (S)-enantiomeric forms, which are expected to be promising, efficient dipolarophiles in highly stereoselective asymmetric nitrone cycloaddition, have been developed, utilizing commercially available L-tert-leucine and (R)-pantolactone, respectively, as chiral precursors.

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