Induced-fit movements in adenylate kinases
- 1 January 1992
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Faraday Discussions
- Vol. 93 (93) , 85-93
- https://doi.org/10.1039/fd9929300085
Abstract
Adenylate kinases have an Mr around 23 000 which classifies them among the smallest phosphoryl group transferring enzymes. In order to prevent phosphoryl transfer to water, i.e. hydrolysis, these enzymes undergo induced-fit motions on substrate binding and assemble/disassemble their catalytic centres during each reaction cycle. Details of these processes have been derived from several X-ray structure analyses. The disturbance of these analyses by crystal-packing effects is discussed.Keywords
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